*** E-MAIL FROM ORGANIZER TO PARTICIPANTS OF WORKSHOP *** Dear Colleagues, It is my pleasure to enclose herewith the programme of the EMBO Workshop on Calcium Signals in the Cell Nucleus. The Workshop commences on August 20th at 13.00 hrs. You have been automatically reserved a room at the Holiday Inn, 20 place de Bordeaux, Strasbourg, which is the venue of the Workshop. The last session of the Workshop takes place on Sunday, August 23rd terminating at 12.10 hrs, followed by lunch. The Workshop Organization will bear the cost for your stay in the Hotel for three nights (August 20, 21 and 22nd), but if you wish to spend an extra night or so, it will be possible on your personal cost. You may indicate it if you wish to do so as soon as possible. Those of you presenting posters may prepare posters to accomodate the dimension: Width - 0.80 meter and height 1.10 meter. I am looking forward to meeting you in Strasbourg in August.` With cordial greetings. Sincerely yours, A.N. Malviya EMBO Workshop: Calcium Signals in the Cell Nucleus August 20 - 23, 1998 VENUE - Holiday Inn, 20 place de Bordeaux, 67000 Strasbourg (Tel. 33-3 88 37 80 14) Programme Thursday 20th August 13.00 - 15.00 Registration 15.00 - 15.10 Welcome: Opening Remarks: Anant N. MALVIYA Chair: Ernesto CARAFOLI 15.10 - 16.00 Opening Lecture: John WALKER: Title to be announced First session Regulation of nuclear calcium pool Chair: Michael J. BERRIDGE: 16.00 - 16.35 Michael H. NATHANSON: Mechanism of long-range Ca2+ signaling in the nucleus 16.35 - 17.10 Atsushi MIYAWAKI: A revolution in calcium imaging: Quantitative calcium imaging with improved yellow cameleons 17.10 - 17.30 Coffee break 17.30 - 18.05 Anant N. MALVIYA: Regulation of nuclear Ca2+-pump ATPase activity by cAMP-dependent protein kinase 18.05 - 18.40 Nullin DIVECHA: Nuclear inositides, diacylglycerol and phosphatidic acid 18.40 - 19.15 Sylvain DELISLE: When retargeted toward the nuclear envelope Ins(1,4,5)P3 receptors stimulate Ins(1,4,5)P3-induced Ca2+-influx 19.15 - 20.00 Welcome Drinks 20.00 Dinner Friday 21st August Chair: Ole H. PETERSEN 08.30 - 09.20 Lecture: Michael J. BERRIDGE: Elementary and global aspects of calcium signalling Second session Cross-talk between nuclear and cytosolic calcium; nuclear pores Chair: Ueli AEBI 09.20 - 09.55 Bernard HIMPENS: Nucleo-cytoplasmic [Ca2+]modulations in cultured cells 09.55 - 10.30 Tullio POZZAN: Intracellular calcium microdomains: where and why ? 10.30 - 10.50 Coffee break 10.50 - 11.25 Anthony K. CAMPBELL: Nuclear signalling, Ca2+ and the intranet 11.25 - 12.00 Michael BRITCH: Mathematical modelling of intranuclear calcium dynamics 12.00 - 12.35 Martin D. BOOTMAN: The cytosolic origin of nucleoplasmic calcium signals 12.35 - 13.10 Shmuel MUALLEM: Compartmentalization and specificity in Ca2+ signaling 13.10 Lunch Second session continued Chair: Oriol BACHS 15.00 - 15.35 Hans OBERLEITHNER: Contraction of nuclear pore complexes visualized with the atomic force microscope 15.35 - 16.10 Jose BUSTAMANTE: Calcium, nuclear pore ion channel gating behavior and nuclear translocation of transcription factors and mRNAs 16.10 - 16.30 Coffee break 16.30 - 17.05 Ernesto CARAFOLI: Calcium in excitation-transcription coupling: the expression of the plasma membrane calcium pump in cerebellar granule neurons is modulated by calcium 17.05 - 17.40 Brian A. HEMMINGS: Regulation of NDR protein kinase by Ca2+/S100B and phosphorylation 17.40 - 18.15 Tobias MEYER: Decoding calcium and diacylglycerol signals by a molecular switch mechanisms for protein kinase C activation 18.40 Departure for reception 19.00 - 20.30 Reception hosted by the Mayor of Strasbourg at the Hôtel de Ville, place Broglie (9, rue Brûlée) Saturday 22nd August Chair : Anant N. MALVIYA 08.30 - 09.20 Lecture: Susan S. TAYLOR: cAMP-dependent protein kinase: structural basis for catalysis, inhibitor and subcellular localization Third session Nuclear calcium in nuclear transport process Chair: Brian A. HEMMINGS 09.20 - 09.55 Ole H. PETERSEN: Transport of calcium and calmodulin between the nucleus and the cytosol: The nucleus as an integrator of calcium and calmodulin signalling 09.55 - 10.30 Oriol BACHS: Calmodulin and nuclear functions 10.30 - 10.50 Coffee Break 10.50 - 11.25 John A. HANOVER: Regulation of nuclear protein transport by calcium and O-GlcNAc glycosylation 11.25 - 12.00 Frank MELCHIOR: The GTPase ran in nuclear protein transport 12.00 - 12.35 Urs F. GREBER: Roles of calcium in adenovirus, nuclear targeting and DNA import into the nucleus 13.00 Lunch 15.00 - 16.00 Poster discussions Fourth session Nuclear calcium in gene transcription Chair : Susan S. TAYLOR 16.00 - 16.35 : Steve FINKBEINER: Mechanisms of calcium- and CREB-dependent gene expression 16.35 - 17.10 Peter HOGAN: Gene regulation by calcineurin and NFAT 17.10 - 17.30 Coffee break 17.30 - 18.05 Hilmar BADING: Mechanisms controlling gene regulation by nuclear and cytoplasmic calcium signals 18.05 - 18.40 Ricardo E. DOLMETSCH: Calcium oscillations increase the efficiency and specificity of gene expression 18.40 - 19.15 : Thomas L. GRUNDSTRÖM: Calcium regulation of basic helix-loop-helix transcription factors (selected from Poster) Sunday 23rd August Chair: Anthony .K. CAMPBELL 08.30 - 09.20 Lecture: Ueli AEBI: Molecular dissection of nuclear pore complex structure and function Fifth session Apoptosis Chair: John A. HANOVER 09.20 - 09.55 Jean-Claude MARTINOU: BAX induces cytochrome-c release from isolated mitochondria 09.55 - 10.30 Patrick ROGUE: Apoptosis, mitochondria and nuclei 10.30 - 10.50 Coffee break 10.50 - 11.25 Luigia SANTELLA: Ca2+-dependent proteolysis in the regulation of the cell cycle 11.25 - 12.00. Kelvin CAIN: Endonuclease and caspase activation during apoptosis 12.00 -12.10 Concluding Remarks: Guy VINCENDON 12.30 Farewell Lunch ----------------------------------------------------------------------------- Simone OTT CNRS UPR 416 - LNMIC 5, rue Blaise Pascal Tel : (33) +3 88 45 66 31 67084 Strasbourg Cedex Fax : (33) +3 88 45 66 05